Latest work from lab published in mBio journal !
We are pleased to share our latest work:
🔬 “Genomic insights into a clade-specific Candida tropicalis lineage with resistance to azoles and immune evasion traits”
📄 https://journals.asm.org/doi/10.1128/mbio.00235-26
In this study, we performed large-scale population genomics and comparative genomic analyses to investigate the emergence and expansion of a clade-specific lineage of Candida tropicalis associated with antifungal resistance.
Key technical insights:
- Identification of a distinct azole-resistant lineage, suggesting clade-restricted evolution of resistance traits
- Enrichment of genomic features linked to adhesion, host interaction, and immune evasion, indicating enhanced pathogenic fitness
- Evidence supporting adaptive evolution within this lineage, potentially facilitating its persistence and dissemination
- Integration of genome-wide variation with population structure frameworks to resolve lineage-specific diversification
- Implications for regional epidemiology, particularly in high-burden settings such as the Asia-Pacific, where C. tropicalis contributes significantly to invasive candidiasis
Collectively, our findings demonstrate how lineage-specific genomic architectures can couple antifungal resistance with virulence-associated traits, providing a framework for tracking high-risk fungal populations and informing surveillance strategies.
We look forward to engaging discussions and feedback from the community.
#FungalGenomics #Candida #AntifungalResistance #PopulationGenomics #HostPathogen #mBio #ComputationalBiology
