Wastewater genome sequencing emerges as a highly sensitive technique for detecting monkeypox infections within a specific area. By analyzing genetic material present in wastewater samples, researchers can identify traces of the monkeypox virus shed by infected individuals, even before clinical cases are reported. This approach offers a proactive and comprehensive method for monitoring the spread of monkeypox, enabling early detection and swift implementation of control measures. Additionally, wastewater surveillance provides valuable insights into the prevalence and dynamics of monkeypox transmission within communities, aiding public health authorities in devising targeted intervention strategies. As a non-invasive and cost-effective tool, wastewater genome sequencing holds promise for enhancing disease surveillance efforts and safeguarding public health against emerging infectious threats like monkeypox.