getENRICH Application !
getENRICH is particularly useful in antimicrobial resistance (AMR) research for several key reasons:
Exploring AMR Mechanisms in Non-Model Organisms: Many organisms involved in AMR, such as environmental bacteria or pathogens from less-studied ecosystems, are non-model organisms with limited genetic data available. Traditional tools may not cover these species, but getENRICH allows researchers to perform functional enrichment analysis even with incomplete or sparse genetic information, helping uncover potential resistance mechanisms in a broader range of species.
Functional Insights into Resistance Genes: AMR is driven by specific genes and pathways, such as those related to efflux pumps, antibiotic degradation, and target modification. getENRICH helps researchers identify and functionally annotate these genes in non-model organisms, providing insights into how resistance genes are expressed and regulated in various contexts.
Comparative Genomics: AMR often spreads through horizontal gene transfer (HGT) across different organisms. By using getENRICH, researchers can compare gene functions between resistant and non-resistant strains or species, highlighting unique gene sets that may be involved in resistance, especially in non-model organisms. This can help identify genes and pathways that are conserved across species or are novel to specific environments or populations.
Adaptability to Environmental and Clinical Isolates: The ability of getENRICH to work with custom gene sets makes it a powerful tool for analyzing data from environmental samples, clinical isolates, or metagenomics studies, which are often central to AMR research. This flexibility is crucial when studying AMR in diverse ecosystems, where organisms may not fit into the typical mold of well-characterized species.
Integration with AMR Databases: Researchers can integrate the results from getENRICH with existing AMR databases (e.g., CARD, ResFinder) to cross-reference functionally enriched genes with known resistance genes. This can help link the discovered gene sets to specific AMR phenotypes, adding value to AMR surveillance and evolutionary studies.
By enabling functional analysis across underrepresented species and environments, getENRICH broadens the scope of AMR research, allowing scientists to uncover novel resistance mechanisms and track the evolution and spread of AMR in previously inaccessible organisms.
Web server @ https://getenrich.igib.res.in/